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AD-mix is a chiral ligand and stands for the Asymmetric dihydroxylation mix. This chemical mixture is employed in the Sharpless asymmetric dihydroxylation reaction. This product is commercially available comes in two variations, AD-mix α and AD-mix β.^[1]

In AD-mix α DHQ2PHAL (top) is the phthalazine adduct with dihydroquinine.

In AD-mix β; DHQD2PHAL is the phthalazine adduct with dihydroquinidine.

One mix is used for each one of the enantiomers. The mix further contains:

• Osmium catalyst potassium osmate K₂OsO₂(OH)₄
• co-oxidant for the regeneration of osmium potassium ferricyanide K₃Fe(CN)₆

[edit] References

1. ↑  Sharpless, K. B., et al. J. Org. Chem. 1992, 57, 2768-2771. (DOI:10.1021/jo00036a003)

[edit] External links

• Catalytic Asymmetric Dihydroxylation of Alkenes at Imperial College London Link