Actinomycin

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Image:Actinomycin.png
Actinomycin
Systematic (IUPAC) name
(Dactinomycin )
Identifiers
CAS number	50-76-0
ATC code	L01 DA01
PubChem	2019
DrugBank	APRD00124
Chemical data
Formula	C₆₂H₈₆N₁₂O₁₆
Mol. weight	1255.42 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	5%
Metabolism	?
Half life	36 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Actinomycin is any of a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces.

It was the first antibiotic shown to have anti-cancer activity, but is not normally used as such, as it is highly toxic, causing damage to genetic material. It is mainly used as an investigative tool in cell biology.

Actinomycin-D is marketed under the trade name Dactinomycin. It binds to DNA duplexes, thereby interfering with the action of enzymes engaged in replication and transcription. Actinomycin-D is one of the older chemotherapy drugs which has been used in therapy for many years. It is a clear, yellow liquid which is administered intravenously and most commonly used in treatment of a variety of cancers.

[edit] External links

A vendor product page about Actinomycin-D: www.fermentek.co.il/actinomycin_d.htm.

This antibiotic-related article is a stub. You can help Wikipedia by expanding it.

Chemotherapeutic agents/Antineoplastic agents (L01) edit - Chemotherapy regimens
Alkylating agents:	Nitrogen mustards: ( Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan). Nitrosoureas: ( Carmustine, Fotemustine, Lomustine, Streptozocin). Platinum: ( Carboplatin, Cisplatin, Oxaliplatin, BBR3464). Busulfan, Dacarbazine, Mechlorethamine, Procarbazine, Temozolomide, ThioTEPA, Uramustine
Antimetabolites:	Folic acid: ( Methotrexate, Pemetrexed, Raltitrexed). Purine: ( Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Tioguanine). Pyrimidine: ( Capecitabine). Cytarabine, Fluorouracil, Gemcitabine
Plant alkaloids:	Taxane: ( Docetaxel, Paclitaxel). Vinca: ( Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics:	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Valrubicin). Bleomycin, Hydroxyurea, Mitomycin
Topoisomerase inhibitors:	Topotecan, Irinotecan, Podophyllum: ( Etoposide, Teniposide).
Monoclonal antibodies:	Alemtuzumab, Bevacizumab, Cetuximab, Gemtuzumab, Panitumumab, Rituximab, Trastuzumab
Photosensitizers:	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Kinase inhibitors:	Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Nilotinib, Sorafenib, Sunitinib, Vandetanib (ZD6474)
Other:	Alitretinoin, Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase, Bexarotene, Bortezomib, Denileukin diftitox, Estramustine, Hydroxycarbamide, Pentostatin, Masoprocol, Mitotane, Pegaspargase, Tretinoin