Alfuzosin

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Image:Alfuzosin.png
Alfuzosin
Systematic (IUPAC) name
N-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)- methyl-amino]propyl] tetrahydrofuran- 2-carboxamide
Identifiers
CAS number	81403-80-7
ATC code	G04 CA01
PubChem	2092
DrugBank	APRD00490
Chemical data
Formula	C₁₉H₂₇N₅O₄
Mol. weight	389.449 g/mol
Pharmacokinetic data
Bioavailability	49%
Protein binding	82%-90%
Metabolism	Hepatic (CYP3A4-mediated)
Half life	10 hours
Excretion	Fecal (69%) and renal (24%)
Therapeutic considerations
Pregnancy cat.	B2(AU) B(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral

Alfuzosin (INN, provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin is marketed by Sanofi Aventis under the brand name Uroxatral®.

[edit] Side effects

The most common side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.

[edit] Contraindications

Alfuzosin should be used with caution in patients with severe renal insufficiency, and should not be prescribed to patients with a known history of QT prolongation or to patients who are taking medications known to prolong the QT interval.

[edit] External links

Uroxatral (manufacturer's website)
Alfuzosin (patient information)

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Urologicals (G04) edit
Acidifiers:	Ammonium chloride, Calcium chloride
Urinary antispasmodics:	Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium
For erectile dysfunction:	Alprostadil, Apomorphine, Moxisylyte, Papaverine, Phentolamine, Sildenafil, Tadalafil, Vardenafil, Yohimbin
Other urologicals:	Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Phenazopyridine, Phenyl salicylate, Succinimide
For benign prostatic hypertrophy:	5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Serenoa repens