Alois Alzheimer

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Aloysius "Alois" Alzheimer (b. June 14 1864 in Marktbreit, Bavaria; d. December 19 1915 in Breslau, now Wrocław, Poland) was a German psychiatrist and neuropathologist and a colleague of Emil Kraepelin. Alzheimer is credited with the first published case of 'presenile dementia', which Kraepelin would later identify as Alzheimer's disease.

Alzheimer's father served in the office of notary public in the family's hometown. Alzheimer attended Aschaffenburg, Tübingen, Berlin, and Würzburg universities. He received a medical degree at Würzburg University in 1887. In the following year, he spent five months assisting mentally ill women, before he took an office in the city mental asylum in Frankfurt am Main: the Städtische Anstalt für Irre und Epileptische (asylum for lunatics and epileptics). Emil Sioli was the dean of that asylum (1852-1922). Another neurologist, Franz Nissl (1860-1919), began to work in that same asylum with Alzheimer, and they knew each other.

Much of Alzheimer's later work on brain pathology made use of Nissl's method of silver staining of the histological sections. Alzheimer was the co-founder and co-publisher of the journal Zeitschrift für die gesamte Neurologie und Psychiatrie. He never wrote a book that he could call his own.

In 1901, Alzheimer observed a patient at the Frankfurt Asylum named Mrs. Auguste Deter. The 51 year-old patient had strange behavioral include a loss of short term memory. This patient would become his obsession over the coming years. In April, 1906, Mrs. Deter died and Alzheimer had the patient records and the brain sent to Munich where he was working at Kraepelin's lab. Together with two Italian physicians, he would use the staining techniques to identify amyloid plaques and neurofibrilary tangles. A speech given on November 3, 1906 would be the first time the pathology and the clinical symptoms of presenile dementia would be presented together.<ref name="AlzBook">Maurer K, Maurer U (2003). Alzheimer The life of a physician and career of a disease. New York: Columbia University Press. ISBN 0231118961.</ref>

Since German was the common language of science and especially of Psychology of the time, Kraepelin's use of Alzheimer's disease in a text book would make the name famous. By 1911, the disease was being used by European physicians to diagnose patients in the US. <ref name="AlzBook"/>

Alzheimer fell ill on the train on the way to the University of Breslau where he had been appointed professor of psychiatry in 1912. Most probably he had a streptococcal infection and subsequent rheumatic fever and kidney failure. He died of heart failure at the age of 51 in Breslau.