Aminophylline

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Image:Aminophylline.png
Aminophylline
Systematic (IUPAC) name
1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Identifiers
CAS number	317-34-0
ATC code	R03 DA05
PubChem	9433
DrugBank	APRD00329
Chemical data
Formula	C₁₆H₂₄N₁₀O₄
Mol. weight	420.427 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	60%
Metabolism	?
Half life	7-9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	P(UK)
Routes	oral, i.v.

Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

1 Properties
2 Mechanism of action
3 Brand names
4 External links

[edit] Properties

It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline to litmus. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.

[edit] Mechanism of action

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.

[edit] Brand names

Phyllocontin
Truphylline

[edit] External links

Link page to external chemical sources.

Medications commonly used in asthma and COPD (primarily R03) edit
Anticholinergics:	Ipratropium, Tiotropium
Short acting β₂-agonists:	Salbutamol, Terbutaline
Long acting β₂-agonists (LABA):	Clenbuterol, Formoterol, Salmeterol
Corticosteroids:	Beclometasone, Budesonide, Fluticasone
Leukotriene antagonists:	Montelukast, Pranlukast, Zafirlukast
Xanthines:	Aminophylline, Theobromine, Theophylline
Mast cell stabilizers:	Cromoglicate, Nedocromil
Combination products:	Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol