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BIMU8

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BIMU8 is a novel compound which acts on an area of the brain stem known as the pre-Botzinger complex. The pre-Botzinger complex has been found to drive respiration. BIMU8 stimulates this area of the brain, causing an increase in the rate of respiration.

The most obvious practical use of BIMU8 is to combine it with opiates in order to counteract the dangerous respiratory depressing properties of the latter. BIMU8 does not affect the painkilling properties of opiates, which means that if combined with BIMU8, large therapeutic doses of opiates could theoretically be given to humans without risking a decrease in breathing rate. Studies have shown this in rat models.

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