Bendroflumethiazide
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| Image:Bendroflumethiazide-2D-skeletal.png | |
| Image:Bendroflumethiazide-3D-vdW.png | |
| Bendroflumethiazide
| |
| Systematic (IUPAC) name | |
| 3-benzyl-5,5-dioxo-9- (trifluoromethyl)-5λ6- thia-2,4-diazabicyclo[4.4.0]deca-7, 9,11-triene-8-sulfonamide | |
| Identifiers | |
| CAS number | 73-48-3 |
| ATC code | C03AA01 |
| PubChem | 2315 |
| DrugBank | APRD00666 |
| Chemical data | |
| Formula | C15H14N3F3O4S2 |
| Mol. weight | 421.417 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Protein binding | 96% |
| Metabolism | extensive |
| Half life | 3-4 hours<ref> Ed. Sean C. Sweetman: Martindale: The complete drug reference, 33, Pharmaceutical Press.</ref> |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
Risk neonatal thrombocytopenia in 3rd trimester<ref>BNF 45 March 2003</ref> |
| Legal status |
POM(UK) |
| Routes | oral |
Bendroflumethiazide INN (formerly BAN bendrofluazide), is a thiazide diuretic, used to treat hypertension.
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[edit] External links
| Antihypertensives (C02) and diuretics (C03) edit | ||
|---|---|---|
| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine | |
| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine | |
| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine | |
| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
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