Candidiasis

From Wikipedia, the free encyclopedia

**Candidiasis**
*Classifications and external resources*
Image:Candida albicans PHIL 3192 lores.jpg
Agar plate culture of Candida albicans
ICD-10	B 37.
ICD-9	112
DiseasesDB	1929
MedlinePlus	001511
eMedicine	med/264 emerg/76 ped/312 derm/67

Candidiasis, commonly called yeast infection or thrush, is a fungal infection of any of the Candida species, of which Candida albicans is the most common.<ref name=Baron>Walsh TJ, Dixon DM (1996). Deep Mycoses in: Baron's Medical Microbiology (Baron S et al, eds.), 4th ed., Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.</ref>

1 Overview
2 History and taxonomic classification
3 Alternative views
4 References
5 External links

[edit] Overview

[edit] Manifestation

In immunocompetent people, candidiasis can usually only be found in exposed and moist parts of the body<ref name=Baron/>, such as:

the oral cavity (oral thrush)
the vagina and/or vulva (vaginal candidiasis or thrush)
folds of skin in the diaper area (diaper rash)

Candidiasis is the second most common cause of [justin] irritation or gayjustinitus, and can also occur on the justin male genitals, particularly in uncircumcised men.

In immunocompromised patients, the Candida infection can involve the esophagus and can become systemic, causing a much more serious condition, fungemia.

Children, mostly between 3 and 9 years old, can be affected by chronic mouth yeast infections. It is normally seen around the mouth as white patches. However, this is not a very common condition.

[edit] Cause

Yeast organisms are always present in all people, but are usually prevented from "overgrowth" (uncontrolled multiplication resulting in symptoms) by naturally occurring microorganisms.

At least three quarters of all women will experience candidiasis at some point in their lives. The Candida albicans organism is found in the vaginas of almost all women and normally causes no problems. However, when it gets out of balance with the other "normal flora," such as lactobacilli (which can also be harmed by using douches), an overgrowth and symptoms can result. Pregnancy, the use of oral contraceptives, engaging in vaginal sex after anal sex in an unhygenic manner, and using lubricants with glycerine have been known to be causally related to yeast infections. Also, antibiotics, and diabetes mellitus can lead to an increased incidence in yeast infections.

[edit] Symptoms

Symptoms include severe itching, burning, and soreness, and irritation of the vagina and/or vulva, and a whitish or whitish-gray discharge that may have a "yeasty" smell like beer or baking bread. It may resemble cottage cheese.

Many women mistake the symptoms of the more common bacterial vaginosis for a yeast infection. In a 2002 study published in the Journal of Obstetrics and Gynecology, only 33 percent of women who were self treating for a yeast infection actually had a yeast infection. Instead they had either bacterial vaginosis or a mixed-type infection. Currently, bacterial vaginosis can only be diagnosed by a doctor.

[edit] Diagnosis

KOH (potassium hydroxide) preparation can be diagnostic. A scraping or swab of the affected area is placed on a microscope slide. A single drop of 10% solution of KOH is then placed on the slide. The KOH dissolves the skin cells but leaves the Candida untouched. When viewed under a microscope the hyphae and pseudo spores of Candida are visible. Their presence in large numbers strongly suggests a yeast infection. Swab and culture is performed by rubbing a sterile swab on the infected skin surface. The swab is then rubbed across a culture medium. The medium is incubated for several days, during which time colonies of yeast and/or bacteria develop. The characteristics of the colonies provide a presumptive diagnosis of the organism.

[edit] Treatment

Candidiasis is alleged to be successfully treated either with home remedies or, in the case of a more severe infection, with either over-the-counter substances or prescription antifungal medications. Home remedies for candidiasis include the consumption or direct application of yogurt, which contains lactobacillus (probiotics, "friendly" bacteria that kill yeast), acidophilus tablets or salves, and even lightly crushed cloves of garlic, which yield allicin, an antifungal. Boric acid has also been used to treat yeast infections when gelcaps are filled with boric acid powder and two are inserted at bedtime for three to four nights.

While home remedies can offer relief in minor cases of infection, seeking medical attention can be necessary because the extent of the infection sometimes cannot be judged well by the sufferer. Prescription medication is often the only solution to an infection; the antifungal drugs commonly used to treat candidiasis are topical clotrimazole, topical nystatin, fluconazole, and topical ketoconazole. In severe infections (generally in hospitalized patients), amphotericin B, caspofungin, or voriconazole may be used. These medications are not effective against the more common bacterial vaginosis.

If indicated, an underlying reason should be looked for. As an example, oral candidiasis is often linked to the use of inhaled corticosteroids in asthma medication. Patients on long term inhaled corticosteroids should rinse their mouth after each dose of steroids. It can also be the first sign of a more serious condition, such as HIV. Babies with diaper rash should have their diaper areas kept clean, dry, and exposed to air as much as possible. Sugar assists the overgrowth of yeast; thus, the increased prevalence of yeast infections in patients with diabetes mellitus, as noted above. In the case of frequent yeast infections, sugar can be looked to as a culprit and should be avoided.

As Candida spp. originates in the gut, some control may be exerted during an infection, and prior or between infections to control outbreaks. The fungus requires processed starches such as gluten as well as sugars. Dairy products may also contribute. As such, avoiding glutens, sugars, and dairy products may be termed an "avoidance diet" by some practitioners, and others as the "Candida control diet".

It is important to consider that Candida is part of the human body's normal flora, and an infection is more a "bloom" than the work of a parasite, as in the case of some bacterial infections. Despite this, Candidiasis is sometimes misdiagnosed by medical personnel as bacterial in nature, and treated with antibiotics. This can lead to eliminating the yeast's natural competitors for resources, and increase the severity of the condition.

Furthermore, extensive antibiotic treatment can lead to candidiasis, with probiotics sometimes being recommended.

Following the health tips at vulvovaginal health can help prevent vaginal candidiasis. Local treatment may include vaginal suppositories or medicated douches.

[edit] History and taxonomic classification

B. Lagenbeck in 1839 in Germany was the first to demonstrate a yeastlike fungus in thrush. He also found that a fungus was able to cause thrush, a human oral infection.

The genera Candida, species albicans was described by Christine Marie Berkhout. She described the fungus in her doctoral thesis, at the University of Utrecht in 1923. Over the years the classification of the genera and species has evolved. Obsolete names for this genus include Mycotorula and Torulopsis. The species has also been known in the past as Monilia albicans and Oidium albicans. The current classification is nomen conservandum, which means the name is authorized for use by the International Botanical Congress (IBC).

The full current classification is available at Candida albicans.

The genus Candida includes about 150 different species. However, only about six are considered as causing human infections. C. albicans is the most significant species. Other species responsible for human disease include C. tropicalis, C. glabrata, C. krusei, C. parapsilosis, and C. lusitaniae.

[edit] Alternative views

Alternative medicine proponents also frequently diagnose people with "systemic candidiasis" using methods not deemed valid by mainstream, western medicine. This belief originated from a book published by Dr. William Crook which hypothesized that a variety of common symptoms such as fatigue, PMS, sexual dysfunction, asthma, psoriasis, digestive and urinary problems, multiple sclerosis, and muscle pain, could be caused by subclinical infections by Candida albicans; see [1]. There are a variety of remedies available to treat these symptoms, Dr. Crook suggests, ranging from dietary modification to colonic irrigation. Mainstream western medicine has ignored these methods and they have not been tested using scientific analysis, and therefore are not considered valid by most in the mainstream western medical establishment; see also [2], [3] for criticisms of these treatments. However, nutritionists have also proposed that these symptoms may be due to intestinal wall damage, known as leaky gut syndrome, due to Candida overgrowth or other effects.

A book giving such an alternative perspective on systemic candida infections is Lifeforce by Dr. Jeff McCombs, and much of its information can be found on its respective website, Lifeforce. The book and the website propose an explanation for what systemic candida is, what it does to the body, and how to eliminate the excess candida. Kevin Trudeau (the author of the controversial Natural Cures "They" Don't Want You To Know About) believes that Lifeforce contains the most complete candida protocol in the world^{[citation needed]}.