Cholecystokinin receptor
From Wikipedia, the free encyclopedia
| cholecystokinin A receptor
| |
| Identifiers | |
| Symbol(s) | CCKAR |
| Entrez | 886 |
| OMIM | 118444 |
| RefSeq | NM_000730 |
| UniProt | P32238 |
| Other data | |
| Locus | Chr. 4 p15.2-p15.1 |
| cholecystokinin B receptor
| |
| Identifiers | |
| Symbol(s) | CCKBR |
| Entrez | 887 |
| OMIM | 118445 |
| RefSeq | NM_176875 |
| UniProt | P32239 |
| Other data | |
| Locus | Chr. 11 p15.4 |
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors. There are two different subtypes CCK1 and CCK2. They are ~50% homologous. The CCK1 receptor binds mostly to Cholecystokinin while CCK2 also binds to gastrin. They are mostly involved in various digestive functions like gastrin-stimulated gastric acid secretion, gastric emptying and gut motility. In the brain, CCK functions as a neuropeptide and CCK receptors are involved in nociception, anxiety, memory and hunger.
