Chordin
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| Chordin | |
|---|---|
| Genetic data | |
| Gene code: | HUGO code:CHRD |
| Protein Structure/Function | |
| Protein type: | chordin family member |
| Functions: | dorsalizing factor |
| Domains: | 4 CHRD domains, 4 VWFC domains |
| Other | |
| Taxa expressing: | many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | extracellular |
Chordin is a polypeptide that dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as Bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.
| Identifiers | |
| Symbol(s) | CHRD |
| Entrez | 8646 |
| OMIM | 603475 |
| RefSeq | NM_003741 |
| UniProt | Q9H2X0 |
| Other data | |
| Locus | Chr. 3 q27 |
| TGF beta signaling pathwayedit | |
|---|---|
| TGF beta superfamily of ligands: | |
| Activin A | Activin B | Anti-müllerian hormone | BMP2 | BMP3 | BMP4 | BMP5 | BMP6 | BMP7 | BMP8a | BMP8b | BMP10| BMP15 | GDF1 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDF10 | GDF11 | GDF15| Inhibin A | Inhibin B | Myostatin | Nodal | TGFβ1 | TGFβ2 | TGFβ3 | |
| Type II receptors: ACVR2A | ACVR2B | AMHR2 | BMPR2 | TGFBR2 | TGFBR3 | |
| Type I receptors: ACVR1A | ACVR1B | ACVR1C | ACVRL1 | BMPR1A | BMPR1B | TGFBR1 | |
| Signal transducers: SMAD1 | SMAD2 | SMAD3 | SMAD4 | SMAD5 | SMAD6 | SMAD7 | SMAD9 | |
| Ligand Inhibitors: Cerberus | Chordin | DAN | Decorin | Follistatin | Gremlin | Lefty | LTBP1 | Noggin | THBS1 | |
| Coreceptors: BAMBI | Cripto Other: SARA |
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