Cisternal progression
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Cisternal progression is a theory of protein transport through the Golgi apparatus inside a cell. It is the main counterpart to the static compartments model.
The Golgi apparatus is composed of a series of stacked compartments through which proteins pass and are modified. In the cisternal progression model, the target proteins remain in a single compartment as the compartment gradually matures. In the static compartments model, proteins are progressively transported from one compartment to the next.
Cisternal maturation was initially a popular theory, but lost favor in the 1980s. It has recently been coming back into favor, as laboratories at the University of Chicago and the University of Tokyo have been able to use new technology to directly observe Golgi compartments maturing. Controversy still remains, however.
[edit] References
- Glick, B.S. and Malhotra, V. (1998). "The curious status of the Golgi apparatus". Cell 95: 883-889.
