Dicumarol
From Wikipedia, the free encyclopedia
| Image:Dicumarol.svg | |
| Dicumarol
| |
| Systematic (IUPAC) name | |
| 2-hydroxy-3-[(2-hydroxy-4-oxo-chromen-3-yl) methyl] chromen-4-one | |
| Identifiers | |
| CAS number | 66-76-2 |
| ATC code | B01AA01 |
| PubChem | 653 |
| DrugBank | APRD00761 |
| Chemical data | |
| Formula | C19H12O6 |
| Mol. weight | 336.295 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Dicumarol (or Dicoumarol) is a anticoagulant that functions by as a Vitamin K antagonist (similar to warfarin).
It is a derivative of coumarin.
[edit] External links
- DDB 30166
- Cullen J, Hinkhouse M, Grady M, Gaut A, Liu J, Zhang Y, Weydert C, Domann F, Oberley L (2003). "Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.". Cancer Res 63 (17): 5513-20. PMID 14500388.
- Mironov A, Colanzi A, Polishchuk R, Beznoussenko G, Mironov A, Fusella A, Di Tullio G, Silletta M, Corda D, De Matteis M, Luini A (2004). "Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport.". Eur J Cell Biol 83 (6): 263-79. PMID 15511084.
- Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz L (2005). "Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.". Arch Biochem Biophys 434 (2): 241-7. PMID 15639223.
- Thanos C, Liu Z, Reineke J, Edwards E, Mathiowitz E (2003). "Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride.". Pharm Res 20 (7): 1093-100. PMID 12880296.
