Enflurane
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| Image:Enflurane2.png | |
| Image:Enflurane-3D-vdW.png | |
| Enflurane
| |
| Systematic (IUPAC) name | |
| 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane | |
| Identifiers | |
| CAS number | 13838-16-9 |
| ATC code | N01AB04 |
| PubChem | 3226 |
| DrugBank | APRD00234 |
| Chemical data | |
| Formula | C3H2ClF5O |
| Mol. weight | 184.492 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 97% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966.
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.
Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.
[edit] Physical properties
| Molecular weight | 184.5 g/mol | ||
| Boiling point (at 1 atm): | 56.5 °C | ||
| MAC : | 1.68 | ||
| Vapor pressure: | 172 mmHg | (at 20°C) | |
| Blood:Gas Partition Coefficient: | 1.9 | ||
| Oil:Gas Partition Coefficient: | 98 |
[edit] External links
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