Epidermal growth factor
From Wikipedia, the free encyclopedia
- "EGF" redirects here. For other uses, see EGF (disambiguation).
| Image:EGF.png | |
| Three dimensional structure of EGF PDB 1EGF | |
| Epidermal growth factor
| |
| Identifiers | |
| Symbol(s) | EGF URG |
| Entrez | 1950 |
| OMIM | 131530 |
| RefSeq | NM_001963 |
| UniProt | P01133 |
| Other data | |
| Locus | Chr. 4 q25 |
Epidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth, proliferation and differentiation. Human EGF is a 6045 Da protein with 53 amino acid residues and three intramolecular disulfide bonds[1]
EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity in turn initiates a signal transduction cascade which results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation. [1]
[edit] See also
[edit] References
- a b Image:Free review.png Epidermal growth factor. J Biol Chem. 1990 May 15; 265(14): 7709-12. PMID 2186024 Free text (PDF - 581K)
- Epidermal growth factor immunoreactive material in the central nervous system: Location and development. Science 1984 Jun 8; 224(4653): 1107-9. PMID 6144184
[edit] External link
- EGF at the Human Protein Reference Database.
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