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Follistatin
Image:Follistatin activin Complex.png The Structure Of The Follistatin:Activin Complex
Other names:	FS, Activin-binding protein
Genetic data
Gene code:	HUGO code:FST
Protein Structure/Function
Structure:	Follistatin:Activin Complex structure
Protein type:	Growth factor
Functions:	Regulates members of the TGF beta superfamily ligands
Domains:	3 FOLN domains, 3 KAZAL domains
Other
Taxa expressing:	Homo Sapiens; homologs: many metazoan phyla
Cell types:	many, placenta, blood, ovary, liver, testis
Subcellular localization:	extracellular
Molecular interactions:	Activin, inhibin, BMP5
Medical/Biotechnological data
Diseases:	polycystic ovary syndrome (PCOS)

Follistatin is a single chain gonadal protein that inhibits Follicle-stimulating hormone release. It binds to and antagonizes Activin, which enhances FSH secretion. There are three known isoforms created by alternative splicing.

Identifiers
Symbol(s)	FST
Entrez	10468
OMIM	136470
RefSeq	NM_013409
UniProt	P19883
Other data
Locus	Chr. 5 q11.2