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Aldolase

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Aldolase
Image:Fructose-1,6-bisphosphate aldolase 4ALD wpmp.png
Enzyme Fructose 1,6-bisphosphate aldolase
PDB Code PDB 4ALD
Organism Human
Tissue Muscle
Complexed molecules fructose 1,6-bisphosphate

Aldolase is an enzyme which catalyses the aldol reaction: The substrate, fructose 1,6-bisphosphate (F-1,6-BP) is broken down into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). This reaction is a part of glycolysis.

β-D-fructose 1,6-phosphate fructose bisphosphate aldolase D-glyceraldehyde 3-phosphate dihydroxyacetone phosphate
Image:Beta-D-fructose-1,6-bisphosphate wpmp.png Image:D-glyceraldehyde-3-phosphate wpmp.png + Image:Glycerone-phosphate wpmp.png
Image:Biochem reaction arrow reversible NNNN horiz med.png
fructose bisphosphate aldolase

Compound C05378 at KEGG Pathway Database. Enzyme 4.1.2.13 at KEGG Pathway Database. Compound C00111 at KEGG Pathway Database. Compound C00118 at KEGG Pathway Database.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

[edit] Mechanism

In mammalian aldolase the key catylitic amino acid residues involved in the reaction are lysine and tyrosine. The tyrosine acts as an efficient hydrogen acceptor while the lysine covalently binds and stabilizes the intermediates. Many bacteria use two magnesium ions in place of the lysine.

Image:ALDO reaction.png

[edit] See also


 

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Glycolysis Metabolic Pathway
Glucose Glucose 6-phosphate Fructose 6-phosphate Fructose 1,6-bisphosphate Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Glyceraldehyde 3-phosphate
Image:D-glucose wpmp.png ATP ADP Image:Alpha-D-glucose-6-phosphate wpmp.png Image:Beta-D-fructose-6-phosphate wpmp.png ATP ADP Image:Beta-D-fructose-1,6-bisphosphate wpmp.png Image:Glycerone-phosphate wpmp.png Image:D-glyceraldehyde-3-phosphate wpmp.png Image:D-glyceraldehyde-3-phosphate wpmp.png NADP+ + Pi NADPH + H+
Image:Biochem reaction arrow foward YYNN horiz med.png Image:Biochem reaction arrow reversible NNNN horiz med.png Image:Biochem reaction arrow foward YYNN horiz med.png Image:Biochem reaction arrow reversible NNNN horiz med.png + Image:Biochem reaction arrow reversible NNNN horiz med.png 2 Image:Biochem reaction arrow reversible YYYY horiz med.png
NADP+ + Pi NADPH + H+
1,3-bisphosphoglycerate 3-phosphoglycerate 2-phosphoglycerate Phosphoenolpyruvate Pyruvate Acetyl Co-A
Image:1,3-bisphospho-D-glycerate wpmp.png ADP ATP Image:3-phospho-D-glycerate wpmp.png Image:2-phospho-D-glycerate wpmp.png H2O Image:Phosphoenolpyruvate wpmp.png ADP ATP Image:Pyruvate wpmp.png CoA + NADPH + H+ NADP+ + CO2 Image:Acetyl co-A wpmp.png
2 Image:Biochem reaction arrow reversible YYYY horiz med.png 2 Image:Biochem reaction arrow reversible NNNN horiz med.png 2 Image:Biochem reaction arrow reversible NYYN horiz med.png 2 Image:Biochem reaction arrow reversible YYYY horiz med.png 2 Image:Biochem reaction arrow foward YYNN horiz med.png 2
ADP ATP H2O ADP ATP


[edit] References

http://pdbdev.sdsc.edu:48346/pdb/molecules/pdb50_5.html

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