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Glucose isomerase

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Glucose phosphate isomerase
Image:Glucose-6-phosphate isomerase 1GZV wpmp.png
Enzyme Phosphoglucose isomerase
PDB Code PDB 1GZV
Organism Pig
Tissue Muscle
Complexed molecules 5-phosphoarabinoate
Symbol(s): GPI
Genetic data
Locus: Chr. 19 q13.1
Database Links
EC number: 5.3.1.9
Entrez: 2821
OMIM: 172400
RefSeq: NM_000175
UniProt: P06744

Glucose isomerase is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose into fructose. In the glycolysis pathway phosphoglucose isomerase converts glucose-6-phosphate to fructose-6-phosphate. These reactions are reversible.

Contents

[edit] In glycolysis

α-D-Glucose 6-phosphate Phosphoglucose isomerase β-D-Fructose 6-phosphate
Image:Glucose-6-phosphate wpmp.png   Image:Fructose-6-phosphate wpmp.png
Image:Biochem reaction arrow reversible NNNN horiz med.png
 
  Phosphoglucose isomerase

Compound C00668 at KEGG Pathway Database. Enzyme 5.3.1.9 at KEGG Pathway Database. Compound C05345 at KEGG Pathway Database. Reaction R00771 at KEGG Pathway Database.

[edit] As a glucose isomerase

D-Glucose Phosphoglucose isomerase D-Fructose
Image:D-glucose wpmp.png   Image:D-fructose wpmp.png
Image:Biochem reaction arrow reversible NNNN horiz med.png
 
  Phosphoglucose isomerase

[edit] Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.

[edit] See also


 

v • d • e</span> 

Glycolysis Metabolic Pathway
Glucose Glucose 6-phosphate Fructose 6-phosphate Fructose 1,6-bisphosphate Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Glyceraldehyde 3-phosphate
Image:D-glucose wpmp.png ATP ADP Image:Alpha-D-glucose-6-phosphate wpmp.png Image:Beta-D-fructose-6-phosphate wpmp.png ATP ADP Image:Beta-D-fructose-1,6-bisphosphate wpmp.png Image:Glycerone-phosphate wpmp.png Image:D-glyceraldehyde-3-phosphate wpmp.png Image:D-glyceraldehyde-3-phosphate wpmp.png NADP+ + Pi NADPH + H+
Image:Biochem reaction arrow foward YYNN horiz med.png Image:Biochem reaction arrow reversible NNNN horiz med.png Image:Biochem reaction arrow foward YYNN horiz med.png Image:Biochem reaction arrow reversible NNNN horiz med.png + Image:Biochem reaction arrow reversible NNNN horiz med.png 2 Image:Biochem reaction arrow reversible YYYY horiz med.png
NADP+ + Pi NADPH + H+
1,3-bisphosphoglycerate 3-phosphoglycerate 2-phosphoglycerate Phosphoenolpyruvate Pyruvate Acetyl Co-A
Image:1,3-bisphospho-D-glycerate wpmp.png ADP ATP Image:3-phospho-D-glycerate wpmp.png Image:2-phospho-D-glycerate wpmp.png H2O Image:Phosphoenolpyruvate wpmp.png ADP ATP Image:Pyruvate wpmp.png CoA + NADPH + H+ NADP+ + CO2 Image:Acetyl co-A wpmp.png
2 Image:Biochem reaction arrow reversible YYYY horiz med.png 2 Image:Biochem reaction arrow reversible NNNN horiz med.png 2 Image:Biochem reaction arrow reversible NYYN horiz med.png 2 Image:Biochem reaction arrow reversible YYYY horiz med.png 2 Image:Biochem reaction arrow foward YYNN horiz med.png 2
ADP ATP H2O ADP ATP


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fr:Glucose isomérase

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