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Glucuronidation is the process of chemically binding a substance to glucuronic acid via a glycosidic bond. The resulting glucuronide is typically much more water soluble than the original substance. The human body uses glucuronidation to excrete a large variety of molecules, including drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids and bile acids. Most of this is done by the liver.

Contents 1 Acyl glucuronidation 2 N-glucuronidation 3 External links 4 References

[edit] Acyl glucuronidation

Acyl glucuronidation is an important metabolic pathway for fluoroquinolone antibiotics.

[edit] N-glucuronidation

[edit] External links

• Species Differences in N-Glucuronidation
• N-glucuronidation of nicotine and cotinine by human liver microsomes...
• N-glucuronidation of trans-3'-hydroxycotinine by human liver microsomes
• Ethnic differences in N-glucuronidation of nicotine and cotinine

[edit] References

• Mannfred A Hollinger, Introduction to Pharmacology, ISBN 0-415-28033-8
• Chang, K. M.; McManus, K.; Greene, J.; Byrd, G. D.; DeBethizy, J. D. Glucuronidation as a metabolic pathway for nicotine metabolism. 1991
• Coffman B.L., King C.D., Rios G.R. and Tephly T.R. The glucuronidation of opioids, other xenobiotics, and androgens by human