Guanethidine

From Wikipedia, the free encyclopedia

Image:Guanethidine.svg
Guanethidine
Systematic (IUPAC) name
2-(2-azocan-1-ylethyl)guanidine
Identifiers
CAS number	645-43-2
ATC code	C02 CC02 S01 EX01
PubChem	3518
DrugBank	APRD01007
Chemical data
Formula	C₁₀H₂₂N₄
Mol. weight	198.309 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	1.5 days
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Guanethidine is an antihypertensive drug that reduces the release of catecholamines. Side effects include orthostatic and exercise hypotension, sexual dysfunction, and diarrhea.

It is no longer available in the US due to side effects and because substantially better drugs are available. It is still licensed in some countries, e.g. UK, for the rapid control of blood pressure in a hypertensive emergency.

Antihypertensives (C02) and diuretics (C03) edit
Antiadrenergic agents (including alpha):	Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine
Vasodilators:	Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine
Other antihypertensives:	Bosentan, Ketanserin
Low ceiling diuretics:	Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine
High ceiling diuretics:	Bumetanide, Furosemide, Torasemide
Potassium-sparing diuretics:	Amiloride, Eplerenone, Spironolactone, Triamterene

Antiglaucoma preparations and miotics (S01E) edit
Sympathomimetics:	Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics:	Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors:	Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents:	Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues:	Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents:	Dapiprazole, Guanethidine