Gummatous

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The classic lesion is the gumma, a granulomatous lesion thought to be caused by reaction to spirochaete in the tissue. Usually found on the face, trunk or extremities, although any organ can be affected. A firm and rubbery necrosis. Forms an amorphous proteinaceous mass with no preserved original architecture. It is restricted to necrosis involving spirochaetal infections (i.e. spirochetes) that cause syphilis.