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H₂ receptors positively coupled to adenylate cyclase via G_s. It is a potent stimulant of cAMP[[1]] production. It increases the intracellular Ca2+ concentrations and release Ca2+ from intracellular stores.

The drug Betazole is an example of a Histamine H2 receptor agonist.

Contents 1 Location 2 Response 3 H2-receptor agonists and antagonists 4 External links

[edit] Location

• Gastric parietal cells (oxyntic cells)
• Vascular smooth muscle
• Neutrophils
• Central nervous system
• Heart
• Uterus

[edit] Response

• Stimulation of gastric acid secretion
• Smooth muscle relaxation
• Inhibit antibody synthesis, T-cell proliferation and cytokine production

[edit] H₂-receptor agonists and antagonists

see H2-receptor agonist and H2-receptor antagonist

[edit] External links

• IUPHAR GPCR Database - H₂ Histamine Receptor