H4 receptor
From Wikipedia, the free encyclopedia
The H4 histamine receptor was first published by Nguyen et al in March of 2001, who also published the gene encoded it in a search of the GenBank databases. Like the other three histamine receptors, it is also a G protein-coupled receptor.
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[edit] Location
H4 is highly expressed in bone marrow and white blood cells and regulates zymosan-induced neutrophil release from bone marrow and subsequent infiltration in the pleurisy model along with L-selectin.<ref name=H4bonemarrow>Takeshita, Keisuke, Kevin B. Bacon and Florian Gantner (July 2004). "Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan". The Journal of Pharmacology and Experimental Therapeutics 310 (1): 272-80. DOI:10.1124/jpet.103.063776. PubMed.</ref> It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus, tonsils, and trachea.<ref name=otherorgans>Bioreagents.com: Histamine H4 Receptor</ref>
[edit] Functions
They have been shown to mediate mast cell chemotaxis.<ref name=chemotaxis>Hofstra, Claudia L., Pragnya J. Desai, Robin L. Thurmond, and Wai-Ping Fung-Leung (June 2003). "Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells". Journal of Pharmacology And Experimental Therapeutics 305 (3): 1212-21. DOI:10.1124/jpet.102.046581. PubMed.</ref> ...and more
[edit] High affinity substances
The following substances have been found to bind with high affinity to this receptor:
[edit] Moderate affinity substances
The following substances have been found to bind with moderate affinity to this receptor:
[edit] Weak affinity substances
The following substances have been found to bind with weak affinity to this receptor:
[edit] References
- Tuan Nguyen, David A. Shapiro, Susan R. George, Vincent Setola, Dennis K. Lee, Regina Cheng, Laura Rauser, Samuel P. Lee, Kevin R. Lynch, Bryan L. Roth, and Brian F. O'Dowd Discovery of a Novel Member of the Histamine Receptor Family The Journal of Molecular Pharmacology Vol. 59, Issue 3, 427-433, March 2001
[edit] Footnotes
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[edit] External links
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