Human serum albumin
From Wikipedia, the free encyclopedia
| Image:ALB structure.png | |
| The structure of human serum albumin complexed with 6 palmitic acid molecules (from PDB 1E7H) | |
| Albumin
| |
| Identifiers | |
| Symbol(s) | ALB |
| Entrez | 213 |
| OMIM | 103600 |
| RefSeq | NM_000477 |
| UniProt | P02768 |
| Other data | |
| Locus | Chr. 4 q13.3 |
Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. The reference range for albumin concentrations in blood is 30 to 50 g/L (3.0 to 5.0 g/dL). It has a serum half-life of approximately 20 days. It has a molecular mass of 67 kDa.
Contents |
[edit] Hypoalbuminemia
Low blood albumin levels can be caused by malnutrition, malabsorption, liver disease, nephrotic syndrome, neoplasia or pregnancy.
[edit] Hyperalbuminemia
Typically is a sign of severe dehydration.
[edit] Amino Acid Sequence
The approximate sequence of human serum albumin is:
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV AASQAALGL
Where the italicized first 24 amino acids are signal and propeptide portions not observed in the transcribed and transported protein but present in the gene. There are 609 amino acids in this sequence with only 585 amino acids in the final product observed in the blood.
[edit] External links
- Human Albumin structure in the Protein data bank [1]
- Human Albumin information in the Swis-Prot/TrEMBL database
- Human Serum Albumin on the Human Protein Reference Database
