Indapamide
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| Indapamide
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| Systematic (IUPAC) name | |
| 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide | |
| Identifiers | |
| CAS number | 26807-65-8 |
| ATC code | C03BA11 |
| PubChem | 3702 |
| DrugBank | APRD01031 |
| Chemical data | |
| Formula | C16H16ClN3O3S |
| Mol. weight | 365.835 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 71-79% |
| Metabolism | Hepatic |
| Half life | 14-18 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Indapamide is a thiazide diuretic drug, usually used in the treatment of hypertension and edema caused by congestive heart failure.
Indapamide is marketed as NATRILIX SR®
NATRILIX SR abridged prescribing information
Contents |
[edit] Form and Composition:
Each sustained-release coated tablet contains 1.5 mg of 1-(4-chloro-3-sulfamyl-benzamido)-2-methylindoline (or indapamide hemihydrate).
[edit] Indication:
Essential hypertension.
[edit] Contraindications:
Hypersensitivity to sulfonamides, Severe renal failure, Hepatic encephalopathy or severe hepatic failure, Hypokalemia.
[edit] Combination treatments:
Natrilix SR may be combined with all nonthiazide antihypertensive agents, with ß-blockers, calcium channel blockers, and ACE inhibitors.
[edit] Drug combinations to be avoided:
Lithium, nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).
[edit] Precautions:
Pregnancy. Lactation. Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.
[edit] Adverse effects:
Hypokalemia, Fatigue, Orthostatic hypotension, Allergic manifestations.
[edit] Dosage and administration:
One tablet daily.
[edit] Overdosage:
Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.
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| Antihypertensives (C02) and diuretics (C03) edit | ||
|---|---|---|
| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine | |
| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine | |
| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine | |
| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
