Interleukin 10
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| Image:IL10 Crystal Structure.png | |
| Crystal structure of monomeric human IL-10 | |
| interleukin 10
| |
| Identifiers | |
| Symbol(s) | IL10 |
| Entrez | 3586 |
| OMIM | 124092 |
| RefSeq | NM_000572 |
| UniProt | P22301 |
| PDB | 2H24 |
| Other data | |
| Locus | Chr. 1 q31-q32 |
Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine, capable of inhibiting synthesis of pro-inflammatory cytokines like Interferon-gamma, IL-2, IL-3, TNFα and GM-CSF by cells such as macrophages and the Type 2 T helper cells. However, it is also stimulatory towards certain T cells, mast cells and B cells.
It is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells and also in a certain subset of activated T cells and B cells.
[edit] Gene and Protein Structure
In humans, the IL-10 gene is located in chromosome 1 and consists of 5 exons.
The IL-10 protein is a homodimer . Each subunit is 178 amino-acids long.
| Interleukins edit |
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IL-1 | IL-2 | IL-3 | IL-4 | IL-5 | IL-6 | IL-7 | IL-8 | IL-9 | IL-10 | IL-11 | IL-12 | IL-13 | IL-14 | IL-15 | IL-16 | IL-17 | IL-18 | IL-19 | IL-20 | IL-21 | IL-22 | IL-23 | IL-24 | IL-25 | IL-26 | IL-27 | IL-28 | IL-29 | IL-30 | IL-31 | IL-32 | IL-33 | |
