Interleukin 14
From Wikipedia, the free encyclopedia
| Interleukin 14
| |
| Identifiers | |
| Symbol(s) | TXNLA HMW-BCGF, IL14 |
| Entrez | 3599 |
| OMIM | 608676 |
| RefSeq | NP_787048 |
| UniProt | L15344 |
| Other data | |
| Locus | Chr. 1 p34.3 |
Interleukin-14 (IL-14) is a cytokine that is also called High molecular weight B-cell growth factor (HMW-BCGF) that controls the growth and proliferation of both normal and cancerous B cells.<ref>Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.</ref> This molecule was also recently designated taxilin.<ref>Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28</ref> IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.
Two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.<ref>Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.</ref> The il14 locus is near the gene for LCK on chromosome 1 in humans.
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