Interleukin 19
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| Image:IL19 Crystal Structure.png | |
| Crystal structure of human IL-19 | |
| Interleukin 19
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| Identifiers | |
| Symbol(s) | IL19 , MDA1, ZMDA1, IL-10C |
| Entrez | 29949 |
| OMIM | 605687 |
| RefSeq | NM_153758 |
| UniProt | Q9UHD0 |
| PDB | 1N1F |
| Other data | |
| Locus | Chr. 1 q32.2 |
Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide.<ref>Chang, C. et al., Crystal Structure of Interleukin-19 Defines a New Subfamily of Helical Cytokines. Journal of Biological Chemistry, 2003, Volume 278, pages 3308-3313.</ref>
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