Interleukin 20
From Wikipedia, the free encyclopedia
| Interleukin 20
| |
| Identifiers | |
| Symbol(s) | IL20 , ZCYTO10, IL10D |
| Entrez | 50604 |
| OMIM | 605619 |
| RefSeq | NM_018724 |
| UniProt | Q9NYY1 |
| Other data | |
| Locus | Chr. 1 q32 |
Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells. <ref>Rich, B.E. Kupper, T.S., Interleukin 20. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006, Volume 5, Number 3, pages 243-250.</ref>
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