Interleukin 22
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| Image:IL22 Crystal Structure.png | |
| Crystal structure of human IL-22 | |
| Interleukin 22
| |
| Identifiers | |
| Symbol(s) | IL22 , ILTIF, zcyto18, IL-TIF, IL-D110, TIFa, TIFIL-23 |
| Entrez | 50616 |
| OMIM | 605330 |
| RefSeq | NM_020525 |
| UniProt | Q9GZX6 |
| PDB | 1M4R |
| Other data | |
| Locus | Chr. 12 q15 |
Interleukin-22 (IL-22) is a cytokine with homology to IL-10 that was originally called IL-10-related T cell-derived inducible factor (IL-TIF). Human IL-TIF activates the transcription factors stat-1 and stat-3 in several hepatoma cell lines and up-regulates production of acute phase proteins such as serum amyloid A, 1-antichymotrypsin and haptoglobin in HepG2 human hepatoma cells.<ref>Dumoutier L., Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl. Acad. Sci. U.S.A. 2000, Volume 97 pages 10144-10149.</ref> IL-22, signals through the interferon receptor-related proteins CRF2-4 and IL-22R.<ref>Xie et al., Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R, Journal of Biological Chemistry, 2000, Volume 275, page 31335-31339.</ref>
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