Interleukin 24
From Wikipedia, the free encyclopedia
| Interleukin 24
| |
| Identifiers | |
| Symbol(s) | IL24 , ST16, mda-7, IL10B, Mob-5, C49A, FISP |
| Entrez | 11009 |
| OMIM | 604136 |
| RefSeq | NM_006850 |
| UniProt | Q13007 |
| Other data | |
| Locus | Chr. 1 q32 |
Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells <ref>Poindexter et al., Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells. Journal of Leukocyte Biology 2005, Volume 78, pages 745-752.</ref> and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.<ref>Wang M, Liang P. Interleukin-24 and its receptors. Immunology, 2005, Volume 114, pages 166-70.</ref> Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.<ref>Fisher PB, et al., mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. Cancer Biology and Therapeutics. 2003, Volume 2, pages S23-37.</ref><ref>M. Sauane et al., Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory Pathways. Cancer Research, 2004, Volume 64, pages 2988-2993.</ref> The gene for IL-24 is located on chromosome 1 in humans.<ref>http://www.genecards.org/cgi-bin/carddisp.pl?gene=IL24</ref>
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