Interleukin 25
From Wikipedia, the free encyclopedia
| Interleukin 25
| |
| Identifiers | |
| Symbol(s) | IL17E , IL-25 |
| Entrez | 64806 |
| OMIM | 605658 |
| RefSeq | NP_073626 |
| UniProt | Q9H293 |
| Other data | |
| Locus | Chr. 14 q11.2 |
Interleukin-25 (IL-25) is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.<ref>Kei Ikeda et al., Mast cells produce interleukin-25 upon FcRI-mediated activation, Blood, 2003, Volume 101, pages 3594-3596.</ref> It is also known as IL-17E.<ref>The HGNC site for IL-25</ref> IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, that stimulate the expansion of eosinophils. This cytokine is an important molecule controling immunity of the gut<ref>Owyang et al., Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract,Journal of Experimental Medicine, 2006, Volume 203, 843-849.</ref> and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.<ref>Buning et al., The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. European Journal of Immunogenetics, 2003, Volume 30, pages 329-333</ref>
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