Interleukin 26
From Wikipedia, the free encyclopedia
| Interleukin 26
| |
| Identifiers | |
| Symbol(s) | IL26 , AK155 |
| Entrez | 55801 |
| OMIM | 605679 |
| RefSeq | NM_018402 |
| UniProt | Q9NPH9 |
| Other data | |
| Locus | Chr. 12 q15 |
Interleukin-26 (IL-26) is a 171-amino acid protein, which is similar in amino acid sequence to interleukin 10. It was originally called AK155 and is composed of a signal sequence, 6 helices, and 4 conserved cysteine residues. IL-26 is expressed in certain herpesvirus-transformed T cells but not in primary stimulated T cells.<ref>A. Knappe, et al., Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. Journal of Virolology, 2000, Volume 74, pages 3881-3887.</ref> IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2.<ref>F. Sheikh, et al., IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Journal of Immunology, 2004, Volume 172, pages 2006-2010.</ref>
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