Interleukin 30
From Wikipedia, the free encyclopedia
| Interleukin 27
| |
| Identifiers | |
| Symbol(s) | IL27 , IL30, p28 |
| Entrez | 246778 |
| OMIM | 608273 |
| RefSeq | NM_145659 |
| UniProt | Q6P676 |
| Other data | |
| Locus | Chr. 16 p11 |
Interleukin-30 (IL-30) is a protein with a molecular weight of 28 Kilodaltons that forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The second chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.<ref>S. Pflanz et al., IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity Volume, 2002, 16, pages 779-790.</ref> This gene for this molecule is now officially called IL-27 under HGNC guidelines.<ref>http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157</ref>
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