Interleukin 33
From Wikipedia, the free encyclopedia
| Interleukin 33
| |
| Identifiers | |
| Symbol(s) | IL33 , C9ORF26, IL1F11, NFHEV |
| Entrez | 90865 |
| OMIM | 608678 |
| RefSeq | NM_033439 |
| UniProt | O95760 |
| Other data | |
| Locus | Chr. 9 p24.1 |
Interleukin 33 (IL-33) is a newly discovered cytokine that is structurally related to IL-1 and induces type 2 cytokine production from helper T cells. This cytokine was previously called NF-HEV because it appeared to have a role as a nuclear factor (NF) in high endothelial venules (HEVs).<ref>E.S. Baekkevold et al., Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. American Journal of Patholology, 2003, Volume 163, pages 69-79. </ref> IL-33 mediates its biological effects by interacting with the orphan IL-1 receptor, ST2, activating intracellular molecules in the NF-κB and MAP kinase signaling pathways, that drive production of type 2 cytokines (e.g. IL-4, IL-5 and IL-13) from polarized Th2 cells. The induction of these type 2 cytokines by IL-33 in vivo is attributed to severe pathological changes observed in mucosal organs.<ref>J. Schmitz et al., IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity, 2005 Volume 23, pages 479-90.</ref>
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