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Image:IL4 Crystal Structure.png
Crystal structure of human IL-4
interleukin 4
Identifiers
Symbol(s)	IL4
Entrez	3565
OMIM	147780
RefSeq	NM_000589
UniProt	P05112
PDB	1H1K
Other data
Locus	Chr. 5 q23-q31

Interleukin-4, abbreviated IL-4, is a cytokine with many roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. This cytokine was co-discovered by Maureen Howard and William Paul and by Dr. Ellen Vitetta and her research group in 1982. The nucleotide sequence for human IL-4 was isolated four years later <ref>Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.</ref> confirming its similarity to a mouse protein called B-cell stimulatory factor-1 (BCSF-1).

[edit] References

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[edit] External links

• Recombinant Human Interleukin-4 from Cornell University
• Interleukin-4 from Allergy Glossary

pl:Interleukina 4

sr:Интерлеукин 4