Interleukin 8
From Wikipedia, the free encyclopedia
| Image:IL8 Crystal Structure.png | |
| Human interleukin 8 crystal structure | |
| interleukin 8
| |
| Identifiers | |
| Symbol(s) | IL8 |
| Entrez | 3576 |
| OMIM | 146930 |
| RefSeq | NM_000584 |
| UniProt | P10145 |
| PDB | 1IL8 |
| Other data | |
| Locus | Chr. 4 q13-q21 |
- IL-8 redirects here. For the congressional district, see Illinois's 8th congressional district.
Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as the Neutrophil Chemotactic Factor.
If a pregnant mother has high level of interleukin-8 it has been found higher risk of getting schizophrenia in the offspring.1 High level of Interleukin 8 has been shown to get lesser chance of good treatment response of antipsychotic medication in schizophrenia. (Zhang XY,2004)
Note: IL-8 was renamed CXCL8 by The Chemokine Nomenclature Subcommittee of the Nomenclature Committee of the International Union of Immunological Societies, although its approved gene symbol remains IL8.
[edit] References
Note 1: Image:Free text.png Brown AS, Hooton J, Schaefer CA, Zhang H, Petkova E, Babulas V, Perrin M, Gorman JM, Susser ES.(2004) Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry. 161(5):889-95. PMID 15121655 (free full text)</br>
