Juxtaglomerular cell

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In the kidney, the juxtaglomerular cells (JG cells) are cells that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells in the wall of the afferent arteriole that delivers blood to the glomerulus. In synthesizing renin, they play a critical role in the renin-angiotensin system and thus in renal autoregulation, the self-governance of the kidney.

In appropriately stained slides, juxtaglomerular cells are distinguished by their granulated cytoplasm.

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Histology at BU 16010loa

Urinary system - Kidney - edit
Renal capsule \| Renal cortex \| Renal medulla (Renal sinus, Renal pyramids) \| Renal calyx \| Renal pelvis
Nephron - Renal corpuscle (Glomerulus, Bowman's capsule) → Proximal tubule → Loop of Henle → Distal convoluted tubule → Collecting ducts Juxtaglomerular apparatus (Macula densa, Juxtaglomerular cells, Extraglomerular mesangial cells) Renal circulation - Renal artery → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Glomerulus → Efferent arterioles → Vasa recta → Arcuate vein→ Renal vein
Renal physiology
Filtration - Ultrafiltration \| Countercurrent exchange Hormones effecting filtration - Antidiuretic hormone (ADH) \| Aldosterone \| Atrial natriuretic peptide Endocrine - Renin \| Erythropoietin (EPO) \| Calcitriol (Active vitamin D) \| Prostaglandins
Assessing Renal function / Measures of dialysis
Glomerular filtration rate \| Creatinine clearance \| Renal clearance ratio \| Urea reduction ratio \| Kt/V \| Standardized Kt/V \| Hemodialysis product