Lepirudin

Image:Lepirudin.png
Lepirudin
Systematic (IUPAC) name
?
Identifiers
CAS number	120993-53-5
ATC code	B01 AE02
PubChem	?
DrugBank	BTD00024
Chemical data
Formula	C₂₈₈H₄₄₈N₈₀O₁₁₀S₆
Mol. weight	6983.5 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	~1.3 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Lepirudin (Refludan ®) is an anticoagulant which functions as a direct thrombin inhibitor.

[edit] External links

DDB 30082
Smythe M, Stephens J, Koerber J, Mattson J (2005). "A comparison of lepirudin and argatroban outcomes.". Clin Appl Thromb Hemost 11 (4): 371-4. PMID 16244762.
"Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin.". Blood. PMID 16690967.
Lubenow N, Eichler P, Lietz T, Greinacher A (2005). "Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3.". J Thromb Haemost 3 (11): 2428-36. PMID 16241940.

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Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01) edit
Vitamin K antagonists:	Acenocoumarol, Clorindione, Dicumarol (Dicoumarol}, Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
Heparin group (Platelet aggregation inhibitors):	Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin
Other Platelet aggregation inhibitors:	Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal
Enzymes:	Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase
Direct thrombin inhibitors:	Argatroban, Bivalirudin, Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran
Other antithrombotics:	Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban
Non-medicinal:	Citrate, EDTA, Oxalate