Lipoprotein lipase
From Wikipedia, the free encyclopedia
| lipoprotein lipase
| |
| Identifiers | |
| Symbol(s) | LPL LIPD |
| Entrez | 4023 |
| OMIM | 238600 |
| RefSeq | NM_000237 |
| UniProt | P06858 |
| Other data | |
| EC number | 3.1.1.34 |
| Locus | Chr. 8 p22 |
Lipoprotein lipase (EC 3.1.1.34) is an enzyme which hydrolyzes lipids in lipoproteins like those found in chylomicrons into fatty acids and an alcohol.
LPL deficiency leads to hypertriglyceridemia (elevated levels of triglycerides).
Lipoprotein lipase is found in endothelial cells lining the blood vessels of the body.
High fat diets have been shown to cause tissue specific overexpression of LPL: this has been implicated in tissue specific insulin resistance and consequent development of type 2 diabetes mellitus
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