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Major Sperm Protein

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The Major Sperm Protein, commonly abbrieviated to MSP, is the most abundant protein in nematode sperm, making up about 15% of the total protein in the sperm cell. It is responsible for the cell's motility.

The MSP molecules are part of the cell cytoskeleton. They are built up into a set of long chains organised into bundles at the front of the cell, and are disassembled at the back. This pushes the cell forward in a process called treadmilling.

Although there are similar amino acid sequences in other organisms, MSP appears to be unique to the sperm of nematodes.

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Proteins of the cytoskeleton

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Microfilaments    Actins | Myosins | Actin-binding proteins
Intermediate filaments    IFAPs | Keratins | Lamins | Neurofilaments | Type III IF proteins
Microtubules    Dyneins | Kinesins | MAPs | Tubulins
Prokaryotic cytoskeleton    Crescentin | FtsZ | MreB
Other    Major Sperm Proteins
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