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Mesoridazine

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Image:Mesoridazine.png
Mesoridazine
Systematic (IUPAC) name
10-[2-(1-methyl-2-piperidyl)ethyl] -2-methylsulfinyl-10H-phenothiazine
Identifiers
CAS number 5588-33-0
ATC code N05AC03
PubChem 4078
DrugBank APRD00610
Chemical data
Formula C21H26N2OS2
Mol. weight 386.576 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 4%
Metabolism Hepatic/Renal
Half life 24 to 48 hours
Excretion Biliary/Renal
Therapeutic considerations
Pregnancy cat.

C (USA)

Legal status

Prescription only

Routes oral, intravenous

Serentil® (mesoridazine besylate) is a neuroleptic drug that is used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. It exerts its actions through a central adrenergic-blocking, a dopamine-blocking, a serotonin-blocking, and a weak anticholinergic action. It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines.



Antipsychotics (N05A) edit
Phenothiazine typical antipsychotics:

Chlorpromazine, Fluphenazine, Mesoridazine, Perphenazine, Prochlorperazine, Promazine, Thioridazine, Trifluoperazine

Other typical antipsychotics:

Chlorprothixene, Droperidol, Flupentixol, Haloperidol, Loxapine, Molindone, Pimozide, Sulforidazine, Thiothixene

Atypical antipsychotics:

Amisulpride, Aripiprazole, Clozapine, Olanzapine, Quetiapine, Risperidone/Paliperidone, Sertindole, Sulpiride, Ziprasidone, Zotepine

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