Metaraminol
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| Image:Metaraminol.svg | |
| Metaraminol
| |
| Systematic (IUPAC) name | |
| 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol | |
| Identifiers | |
| CAS number | 54-49-9 |
| ATC code | C01CA09 |
| PubChem | 5906 |
| DrugBank | APRD00555 |
| Chemical data | |
| Formula | C9H13NO2 |
| Mol. weight | 167.205 g/mol |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | ~45% |
| Metabolism | Hepatic |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
POM(UK) |
| Routes | Intravenous |
Metaraminol (INN, trade name Aramine®) is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist.
Metaraminol is also used in the treatment of priapism. Although not approved for this use, it appears to be effective.<ref name = McDonald>McDonald M, Santucci R (2004). "Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol.". Int Braz J Urol 30 (2): 121-2. PMID 15703094.</ref><ref name = Koga>Koga S, Shiraishi K, Saito Y (1990). "Post-traumatic priapism treated with metaraminol bitartrate: case report.". J Trauma 30 (12): 1591-3. PMID 2258979.</ref><ref name = Block>Block T, Sturm W, Ernst G, Staehler G, Schmiedt E (1988). "[Metaraminol in therapy of various forms of priapism]". Urologe A 27 (4): 225-9. PMID 3140463.</ref>
[edit] References
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| Adrenergic and dopaminergic agents (C01CA)edit | ||
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Dobutamine, Dopamine, Epinephrine, Fenoldopam, Isoprenaline, Metaraminol, Midodrine, Norepinephrine, Octopamine, Phenylephrine | ||
