Necrosis

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Necrosis (in Greek Νεκρός = Death) is the name given to accidental death of cells and living tissue. Necrosis is less orderly than apoptosis, which is part of programmed cell death. In contrast with apoptosis, cleanup of cell debris by phagocytes of the immune system is generally more difficult, as the disorderly death generally does not send cell signals which tell nearby phagocytes to engulf the dying cell. This lack of signalling makes it harder for the immune system to locate and recycle dead cells which have died through necrosis than if the cell had undergone apoptosis. The release of intracellular content after cellular membrane damage is the cause of inflammation in necrosis.

1 Causes
2 Morphologic patterns
3 Arachnogenic necrosis
4 Footnotes
5 See also

[edit] Causes

There are many causes of necrosis including injury, infection, cancer, infarction, toxins and inflammation. Severe damage to one essential system in the cell leads to secondary damage to other systems, a so-called "cascade of effects". Necrosis can arise from lack of proper care to a wound site. Necrosis is accompanied by the release of special enzymes, that are stored by lysosomes, which are capable of digesting cell components or the entire cell itself. The injuries received by the cell may compromise the lysosome membrane, or may initiate an unorganized chain reaction which causes the release in enzymes. Unlike in apoptosis, cells that die by necrosis may release harmful chemicals that damage other cells. Biopsy material necrosis is halted by fixation or freezing.

[edit] Morphologic patterns

There are seven distinctive morphologic patterns of necrosis:

Coagulative necrosis – typically seen in hypoxic environments (e.g. myocardial infarction, infarct of the spleen). Cell outlines remain after cell death and can be observed by light microscopy.
Liquefactive necrosis – is associated with cellular destruction and pus formation (e.g. pneumonia); often seen with nervous tissue.
Gummatous necrosis – is restricted to necrosis involving spirochaetal infections(e.g. syphilis)
Haemorrhagic necrosis – is due to blockage of the venous drainage of an organ or tissue and occurs in testicular torsion.
Caseous necrosis – is a mix of coagulative necrosis and liquefactive necrosis (e.g. tuberculosis)
Fatty necrosis – results from the action of lipases on fatty tissues (e.g. acute pancreatitis, breast tissue necrosis)
Fibrinoid necrosis – caused by immune-mediated vascular damage. It is marked by deposition of fibrin-like proteinaceous material in arterial walls, which appears smudgy and eosinophilic on light microscopy.

[edit] Arachnogenic necrosis

Spider bites are cited as causing necrosis in some areas. These claims are widely disputed. In the US at least, only the bites of spiders in the genus Loxosceles or Brown Recluse have been proven to consistently cause necrosis.<ref name="Science1957-Atkins">Atkins J, Wingo C, Sodeman W (1957). "Probable cause of necrotic spider bite in the Midwest". Science 126 (3263): 73. PMID 13442644.</ref> Many other spider species are claimed to cause necrosis but in most cases firm evidence is lacking. Partially this is because the early bite is often painless and the spider species cannot be identified.

Spiders proven to cause necrosis:

Loxosceles spiders, including the brown recluse in the midwestern United States and the Chilean recluse in South America

Spiders suspected of, but not shown to cause necrosis:

White-tailed spiders in Australia and New Zealand<ref name="MJA2003-Isbister">Isbister G, Gray M (2003). "White-tail spider bite: a prospective study of 130 definite bites by Lampona species.". Med J Aust 179 (4): 199-202. PMID 12914510.</ref>
Hobo spider in northwestern USA<ref name="Annemergmed2004-Vetter">Vetter R, Isbister G (2004). "Do hobo spider bites cause dermonecrotic injuries?". Ann Emerg Med 44 (6): 605-7. PMID 15573036.</ref>
Sac spider in United States and Australia<ref name="AmJTropMedHyg2006-Vetter">Vetter R, Isbister G, Bush S, Boutin L (2006). "Verified bites by yellow sac spiders (genus Cheiracanthium) in the United States and Australia: where is the necrosis?". Am J Trop Med Hyg 74 (6): 1043-8. PMID 16760517.</ref>