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Nitrogen mustard

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The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. Although their common use is medicinal, in principle these compounds may also be used for chemical warfare purposes.

The prototype nitrogen mustard drug is mustine which is no longer commonly in use but was the first drug to be used as an anticancer chemotherapeutic. It is a schedule 1 substance in the Chemical Weapons Convention. Other nitrogen mustards include cyclophosphamide, chlorambucil, uramustine and melphalan.

Nitrogen mustards act by exerting radiomimetic properties on the cytogenetic material of the cell (chromosomes) ie; the effects seen are similar to genetic material which has been exposed to radiation.

Ovation Pharma bought the rights to nitrogen mustard ^{[citation needed]}. A New York Times article has mentioned that only about 5000 people use therapeutic nitrogen mustard in the United States.^{[citation needed]}

Examples of nitrogen mustards that can be used for chemical warfare purposes and their military weapon designations include:

All belligerent nations stock-piled large amounts of munitions containing nitrogen mustard gas during the Second World War, but none were used in combat. As with all types of mustard gas, nitrogen mustard is a powerful and persistent blister agent.

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Image:WMD-chemical.svg This article forms part of the series <center>Chemical warfare
Blood agents:	Cyanogen chloride (CK) – Hydrogen cyanide (AC)
Blister agents:	Lewisite (L) – Sulfur mustard gas (HD, H, HT, HL, HQ) – Nitrogen mustard gas (HN1, HN2, HN3)
Nerve agents:	G-Agents: Tabun (GA) – Sarin (GB) – Soman (GD) – Cyclosarin (GF) – GV \| V-Agents: VE – VG – VM – VX
Pulmonary agents:	Chlorine – Chloropicrin (PS) – Phosgene (CG) – Diphosgene (DP)
Incapacitating agents:	Agent 15 (BZ) – KOLOKOL-1
Riot control agents:	Pepper spray (OC) – CS gas – CN gas (mace) – CR gas	v • d • e</div>