Nodular sclerosis
From Wikipedia, the free encyclopedia
| ICD-10 | C81.1 |
|---|---|
| ICD-9 | 201.5 |
| ICD-O: | 9663/3-9667/3 |
Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma which is the most common subtype of HL in developed countries. It usually affects females more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar RS cells surrounded by fibrotic collagen bands.
The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells (RS cells) into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment.
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