From Wikipedia, the free encyclopedia
| Image:Norethisterone.svg
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| Norethisterone
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| Systematic (IUPAC) name
|
| (8R,9S,10R,13S,14S,17S)- 17-ethynyl-17-hydroxy- 13-methyl-1,2,6,7,8,9,10,11,12,14,15, 16- dodecahydrocyclopenta[a] phenanthren-3-one
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| Identifiers
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| CAS number
| 68-22-4
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| ATC code
| G03AA05
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| PubChem
| 6230
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| DrugBank
| APRD00679
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| Chemical data
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| Formula
| C20H26O2
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| Mol. weight
| 298.419 g/mol
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| Pharmacokinetic data
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| Bioavailability
| ?
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| Protein binding
| >95%
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| Metabolism
| ?
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| Half life
| 7 hours
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| Excretion
| ?
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| Therapeutic considerations
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| Pregnancy cat.
|
?
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| Legal status
|
|
| Routes
| ?
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Norethisterone (or norethindrone) is a molecule used in hormonal contraceptives. Norethisterone is a synthetic form, and therefore agonist, of the naturally occurring female sex hormone, progesterone. It is a member of the progestagen family and can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with oestrogen), or to postpone a period.
| Sex hormones and related medications (primarily G03, also L02, H01C) edit
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|
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Progestogens:
(receptor) |
Desogestrel,
Drospirenone,
Dydrogesterone,
Ethisterone,
Etonogestrel,
Ethynodiol diacetate,
Gestodene,
Gestonorone,
Levonorgestrel,
Lynestrenol,
Medroxyprogesterone,
Megestrol,
Norelgestromin,
Norethisterone,
Norethynodrel,
Norgestimate,
Norgestrel,
Norgestrienone,
Tibolone
Antiprogestogen:
Mifepristone
|
Androgens:
(receptor) |
Androstanolone,
Fluoxymesterone,
Mesterolone,
Methyltestosterone,
Testosterone,
(see also anabolic steroids)
Antiandrogens:
Bicalutamide,
Cyproterone,
Flutamide,
Nilutamide,
Spironolactone
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Estrogens:
(receptor) |
Chlorotrianisene,
Dienestrol,
Diethylstilbestrol,
Estradiol,
Estriol,
Estrone,
Ethinylestradiol,
Fosfestrol,
Mestranol,
Polyestradiol phosphate
Selective estrogen receptor modulator:
Bazedoxifene,
Clomifene,
Fulvestrant,
Raloxifene,
Tamoxifen,
Toremifene
Aromatase inhibitor:
Aminogluthetimide,
Anastrozole,
Exemestane,
Formestane,
Letrozole,
Vorozole
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Gonadotropins:
(FSHR/LHCGR) |
ovulation stim.:
Clomifene,
Urofollitropin
Antigonadotropins:
Danazol,
Gestrinone
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GnRH:
(receptor) |
Gonadotropin-releasing hormone agonist:
Buserelin,
Goserelin,
Leuprorelin,
Nafarelin,
Triptorelin
Gonadotropin-releasing hormone antagonist:
Abarelix
|
