Oct-4
From Wikipedia, the free encyclopedia
| POU domain, class 5, transcription factor 1
| |
| Identifiers | |
| Symbol(s) | POU5F1 OTF3 |
| Entrez | 5460 |
| OMIM | 164177 |
| RefSeq | NM_002701 |
| UniProt | Q01860 |
| Other data | |
| Locus | Chr. 6 p21.31 |
Oct-4 is an abbreviation of Octamer-4. It is a homeodomain transcription factor of the POU family. This protein is critically involved with self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will actually cause differentiation of the cells <ref>Niwa, H., J. Miyazake, A. Smith (2000). "Quantitative expression of Oct3/4 defines differentiation, dedifferentiation, or self-renewal of ES Cells". Nature Genetics 24: 372-376.</ref>.
[edit] See also
- Enhancer
- Histone
- Nanog (transcription factor)
- Pribnow box
- Promoter
- RNA polymerase
- Sox2
- Transcription factors
- Gene regulatory network
- Bioinformatics
[edit] Sources
- funakoshi PDF
- chemicon "Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state."
- Young Lab- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
[edit] Cited references
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