Phi-X174 phage
From Wikipedia, the free encyclopedia
| Phi-X174 phage | ||||||||
|---|---|---|---|---|---|---|---|---|
| Virus classification | ||||||||
|
The Phi-X174 phage was the first organism to have its DNA-based genome sequenced by Fred Sanger and his team in 1977<ref>Sanger F, Air GM, Barrell BG, Brown NL, Coulson AR, Fiddes CA, Hutchison CA, Slocombe PM, Smith M., Nucleotide sequence of bacteriophage phi X174 DNA, Nature. 1977 Feb 24;265(5596):687-95</ref>. In 1962, Walter Fiers had already demonstrated the physical, covalently closed circularity of Bacteriophage PhiX-174 DNA<ref>Fiers, W., and R. L. Sinsheimer, The structure of the DNA of bacteriophage PhiX 174. III. Ultracentrifuge evidence for a ring structure, J. Mol. Biol. 5:424-434, 1962</ref>.
This phage has a very small amount of DNA. It has 11 genes in 5386 bases (it is single stranded) in a circular topology. Several of them expressing similar function in two groups. The GC content is 44% and 95% of nucleotides are coding genes.
[edit] See also
[edit] References
<references/>
[edit] External links
 | This virus-related article is a stub. You can help Wikipedia by expanding it. |
