Plectin
From Wikipedia, the free encyclopedia
| plectin 1, intermediate filament binding protein 500kDa
| |
| Identifiers | |
| Symbol(s) | PLEC1 EBS1 |
| Entrez | 5339 |
| OMIM | 601282 |
| RefSeq | NM_000445 |
| UniProt | Q15149 |
| Other data | |
| Locus | Chr. 8 q24 |
Plectin is a giant protein (c500 kDa) which binds actin, microtubules and intermediate filaments. It binds actin through a CH domain close to the N-terminus. Plectin is localised to the hemidesmosome (a stud or rivet-like structure on the inner basal surface of keratinocytes in the epidermis of skin), where it cross-links the intermediate filament system to the hemidesmosome itself.
[edit] References
- University of Edinburgh http://www.bms.ed.ac.uk/research/others/smaciver/Encyclop/ABP-P/Plectin.htm
