Proteinase 3
From Wikipedia, the free encyclopedia
| proteinase 3
| |
| Identifiers | |
| Symbol(s) | PRTN3 |
| Entrez | 5657 |
| OMIM | 177020 |
| RefSeq | NM_002777 |
| UniProt | P24158 |
| Other data | |
| Locus | Chr. 19 p13.3 |
Proteinase 3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
